Therapeutic Targeting of RNA Splicing in Cancer
نویسندگان
چکیده
RNA splicing is a key regulatory step in the proper control of gene expression. It highly dynamic process orchestrated by spliceosome, macro-molecular machinery that consists protein and components. The dysregulation has been observed many human pathologies ranging from neurodegenerative diseases to cancer. recent identification recurrent mutations core components spliceosome hematologic malignancies advanced our knowledge how alterations contribute disease pathogenesis. This review article will discuss current understanding aberrant regulation drives tumor initiation progression. We also therapeutic modalities highlight emerging technologies designed target for cancer treatment.
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ژورنال
عنوان ژورنال: Genes
سال: 2023
ISSN: ['2073-4425']
DOI: https://doi.org/10.3390/genes14071378